Nicolas Leoz has resigned from FIFA s executive committee and also as president of Conmebol for health reasons.
The 84-year-old, who had heart surgery for the fourth time in December, has headed Conmebol since 1986, and been on FIFA s executive committee since 1998.
I have invited you to this meeting to share with you my retirement from FIFA, Leoz said, before adding that he had informed president Sepp Blatter of the news.
I m announcing my retirement from all FIFA committees because it s important for my life, the Paraguayan said.
I still have good mental health but physically I m often impeded. I feel very happy because I m retiring with the tranquility and knowledge of having done a sincere and honest job.
In 2010 Leoz was accused by the BBC programme Panorama of having received money from ISL, a former marketing partner of FIFA. He denied any wrongdoing.
The findings of a FIFA investigation into accusations of bribery involving ISL had been due in March but could now be put forward as early as this week.